Unconjugated Hyperbilirubinemia During Treatment with Chenodeoxycholic Acid
نویسندگان
چکیده
منابع مشابه
Pharmacological therapies for unconjugated hyperbilirubinemia.
Severe unconjugated hyperbilirubinemia, seen mainly in neonates, may cause kernicterus and death. Conventional treatment for severe unconjugated hyperbilirubinemia consists of phototherapy and exchange transfusion. Phototherapy, however, has several known disadvantages while exchange transfusion is associated with a significant morbidity, and even mortality. These harmful effects indicate the n...
متن کاملUrinary excretion of biopyrrin in unconjugated hyperbilirubinemia
Biopyrrin is an oxidative metabolite of bilirubin. Biopyrrin is a tripyrrol moiety of bilirubin, including two regioisomers (biotripyrrin-a, 1,14,15,17tetrahydro-2,7,13-trimethyl-1,14-deoxy-3-vinyl-16Htripyrrin-8,12-dipropionic acid and biotripyrrin-b, 1,14,15,17-tetrahydro-3,7,13-trimethyl-1,14-deoxy2-vinyl-16H-tripyrrin-8,12-dipropionic acid: Fig. 1). For many years, bilirubin was regarded as...
متن کاملbefore and during chenodeoxycholic acid therapy
was found, but only after five and 10 days of treatment was the increase statistically significant when compared with basal levels. Similar changes were observed for guanosine 3':5'-phosphate (cyclic GMP), but percentage increases were higher than for cyclic AMP. Initial diarrhoea disappeared spontaneously, and at 15 days the levels of both cyclic nucleotides were not significantly different fr...
متن کاملEffective treatment of unconjugated hyperbilirubinemia with oral bile salts in Gunn rats.
BACKGROUND & AIMS We tested the hypothesis that oral administration of bile salts, which are known to increase the biliary excretion of unconjugated bilirubin (UCB), decreases unconjugated hyperbilirubinemia in the Gunn rat model. METHODS Adult Gunn rats were fed a standard diet or the same diet supplemented with 0.5 weight % ursodeoxycholic acid (UDCA) or cholic acid (CA) for 1 or 6 weeks. U...
متن کاملEffects of side chain length on ionization behavior and transbilayer transport of unconjugated dihydroxy bile acids: a comparison of nor-chenodeoxycholic acid and chenodeoxycholic acid.
13C-NMR spectroscopy was used to examine the effect of side chain length on the ionization properties and transmembrane transport rate of 3 alpha,7 alpha-dihydroxy bile acids. When solubilized in taurocholate micelles, [23-13C]nor-chenodeoxycholic acid (nor-CDCA) had a pKa of 6.1, similar to that of CDCA (pKa 6.2), its C24 homologue. In unilamellar phosphatidylcholine vesicles, the pKa of nor-C...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 1979
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(79)80021-9